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  • LeukoPrint®

    Hematologic Malignancy Molecular Karyotyping Test

    LeukoPrint® is a molecular karyotyping test designed to complement conventional cytogenetic approaches in hematologic malignancy diagnostics. lt employs shallow whole-genome sequencing (sWGS) to deliver comprehensive, high-resolution genome coverage for the detection of clinically significant copy number aberration (CNA) and copy neutral loss of heterozygosity (CN-LOH), providing advantages over traditional karyotyping and fluorescence in situ hybridization (FlSH).

    Molecular karyotyping

    Precision diagnosis

    Risk stratification

    Therapy guidance

    Highlights

    • LeukoPrint® performs shallow whole-genome sequencing (sWGS, at 1× coverage) on bone marrow samples to identify genome-wide CNA and CN-LOH.
    • When combined with traditional cytogenetic methods, it enables more accurate diagnosis,classification, risk-stratification, and ultimately guides risk-adapted therapy for hematologic malignancies.
  • Advantages

    ◉ No cell culture

    Faster results, no culture failures.

    ◉ Genome-wide CNA/CN-LOH

    Sensitive, automated detection of key abnormalities missed

    by standard methods.

    ◉ Greater diagnostic yield

    Accurately detects small CNAs (≥1 Mb) even in low-tumor or

    ambiguous samples.

    ◉ Clinical actionability

    Supports risk-adapted therapy with ELN/IPSS-/mSMART

    integration.

  • Testing time

    First-line diagnostic adjunct

    enhances sensitivity in

    suspected hematologic

    malignancies.

    Karyotyping failure rescue

    provides full genomic profiling when standard

    karyotyping fails.

    Complex case resolution

    reveals cryptic abnormalities when karyotyping/FISH

    are inconclusive.

    Critical variant detection

    identifies CN-LOH

    undetectable by

    karyotyping/FISH.

  • Specifications

    ◉ Indicated subjects:Patients with suspected or confirmed hematologic malignancies

    ◉ Sample requirement:2-4 mL bone marrow

    ◉ Result readout:CNA and CN-LOH

    ◉ Turnaround time (TAT):10 working days

  •  

    How it works

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    Order

    Consult your doctor to order through a local healthcare partner

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    Blood draw

    2-4 mL bone marrow is collected and delivered to the central lab

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    Testing

    Detection is performed using next generation sequencing (NGS) platform

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    Reporting

    Results are ready within 10 working days after the sample arrives at the central lab

  • Please review the instructions to gain a better understanding of LeukoPrint® and assess whether it meets your needs.

    Download the Instructions

  • References

    1.Lyu X, Li T, Zhu D, et al. Whole-genome sequencing as an alternative to analyze copy number abnormalities in acute myeloid leukemia and myelodysplastic syndrome. Leuk Lymphoma. 2022;63(10):2301-2310. doi:10.1080/10428194.2022.2080821

    2.Zhang X, Yang Z, Yan S, et al. Clinical Potential of Copy Number Aberration as a Diagnostic and Prognostic Biomarker in Lymphoma. Technol Cancer Res Treat. 2025;24:15330338251383634. doi:10.1177/15330338251383634

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